2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol inhibits MDM2 and induces apoptosis in breast cancer cells through a p53-independent pathway
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- 作者：Jingwen Xua ; Mengting Hana ; Jiwei Shena ; Qi Guanb ; Zhaoshi Baia ; Binyue Langa ; Huijuan Zhanga ; Zengqiang Lia ; Daiying Zuoa ; zuodaiying@163.com" class="auth_mail" title="E-mail the corresponding author ; Weige Zhangb ; Yingliang Wua ; yingliang_1016@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Combretastatin A-4 ; MDM2 ; p53 ; Apoptosis ; Breast cancer
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：383
- 期：1
- 页码：9-17
- 全文大小：3698 K
文摘
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SQ dissociates the MDM2-p53 complex and directly induces MDM2 degradation.
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SQ degrades MDM2 through ubiquitin-dependent proteasome pathway.
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SQ induces caspase-dependent but p53-independent apoptosis.
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SQ exhibits superior in vivo efficacy and low toxicity compared with CA-4.