Glucose 6-phosphate dehydrogenase deficient subjects may be better “storers” than donors of red blood cells
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- 作者：Vassilis L. Tzounakasa ; Anastasios G. Kriebardisb ; Hara T. Georgatzakoua ; Leontini E. Foudoulaki-Paparizosc ; 1 ; Monika Dzieciatkowskad ; Matthew J. Witherd ; Travis Nemkovd ; Kirk C. Hansend ; Issidora S. Papassideria ; Angelo D&rsquo ; Alessandrod ; angelo.dalessandro@ucdenver.edu" class="auth_mail" title="E-mail the corresponding author ; Marianna H. Antoneloua ; manton@biol.uoa.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AnnV ; Annexin V ; ATP ; adenosine triphosphate ; CPD ; citrate-phosphate-dextrose ; DPG ; 2 ; 3-diphosphoglycerate ; Hct ; hematocrit ; Hb ; hemoglobin ; H2O2 ; hydrogen peroxide ; G6PD ; glucose-6-phosphate dehydrogenase ; G6PD&minus ; G6PD deficiency ; GSH ; reduced glutathione ; GSSG ; oxidized glutathione ; K+ ; potassium ; LDH ; lactate dehydrogenase ; MCH ; mean corpuscular haemoglobin ; MCV ; mean corpuscular volume ; MetHb ; methemoglobin ; MPs ; microparticles ; microvesicles ; NAD+ ; oxidized form of nicotinamide adenine
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：152-165
- 全文大小：3495 K
文摘
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Red blood cells donated by G6PD-deficient donors store well compared to control cells.
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To simulate transfusion outcomes an in vitro model of transfusion was used showing that.
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G6PD− cells could be susceptible to hemolysis and oxidative stress post-transfusion.
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Recipient G6PD− plasma better tolerates exposure to long stored healthy RBCs.