CD8¦Á⁺ Dendritic Cells Are an Obligate Cellular Entry Point for Productive Infection by Listeria monocytogenes

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• 作者：Brian  ; T. Edelson¹ ; Tara  ; R. Bradstreet¹ ; Kai Hildner¹ ;   ; ² ;   ; ³ ; Javier  ; A. Carrero¹ ; Katherine  ; E. Frederick¹ ; Wumesh KC¹ ; Roger Belizaire¹ ; Taiki Aoshi¹ ;   ; ⁴ ; Robert  ; D. Schreiber¹ ; Mark  ; J. Miller¹ ; Theresa  ; L. Murphy¹ ; Emil  ; R. Unanue¹ ; Kenneth  ; M. Murphy¹ ;   ; ² ;   ; ^{kmurphy@wustl.edu}
• 刊名：Immunity
• 出版年：2011
• 出版时间：26 August 2011
• 年：2011
• 卷：35
• 期：2
• 页码：236-248
• 全文大小：2157 K

文摘

Summary

CD8¦Á⁺ dendritic cells (DCs) prime cytotoxic T lymphocytes during viral infections and produce interleukin-12 in response to pathogens. Although the loss of CD8¦Á⁺ DCs in Batf3^{??/sup> mice increases their susceptibility to several pathogens, we observed that Batf3??/sup> mice exhibited enhanced resistance to the intracellular bacterium Listeria monocytogenes. In wild-type mice, Listeria organisms, initially located in the splenic marginal zone, migrated to the periarteriolar lymphoid sheath (PALS) where they grew exponentially and induced widespread lymphocyte apoptosis. In Batf3??/sup> mice, however, Listeria organisms remain trapped in the marginal zone, failed to traffic into the PALS, and were rapidly cleared by phagocytes. In addition, Batf3??/sup> mice, which lacked the normal population of hepatic CD103+ peripheral DCs, also showed protection from liver infection. These results suggest that Batf3-dependent CD8¦Á+ and CD103+ DCs provide initial cellular entry points?within the reticuloendothelial system by which Listeria establishes productive infection.}