Targeting the norepinephrinergic system in Parkinson's disease and related disorders: The locus coeruleus story

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• 作者：Yannick Vermeiren^a ; ^b ; ^{yannick.vermeiren@uantwerp.be} ; Peter P. De Deyn^a ; ^b ; ^c ; ^{dedeyn@skynet.be}
• 关键词：Dementia with Lewy bodies ; Brainstem nuclei ; Monoamines ; 3-methoxy-4-hydroxyphenylglycol (MHPG) ; Biomarkers ; Pharmacotherapy
• 刊名：Neurochemistry International
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：102
• 期：Complete
• 页码：22-32
• 全文大小：3532 K
• 卷排序：102

文摘

Parkinson's disease (PD) is characterized by loss of locus coeruleus (LC) neurons. LC lesioning occurs earlier and to greater extent than that of the substantia nigra. There is a solid link between an altered LC-norepinephrine (NE) system and dementia. Peripheral/central MHPG, NE's main metabolite, may serve as an early marker for PD. Therapeutic strategies enhancing NE signaling may hold great potential to treat PD.