Jump in the fire — heat shock proteins and their impact on ovarian cancer therapy

详细信息    查看全文

• 作者：M.B. Stope^a ; ^{matthias.stope@uni-greifswald.de" class="auth_mail" title="E-mail the corresponding author}Author Vitae ; D. Koensgen^b ; M. Burchardt^a ; N. Concin^c ; M. Zygmunt^b ; A. Mustea^b
• 关键词：OC ; ovarian cancer ; HSP ; heat shock proteins ; 17-AAG ; 17-allylamino-demethoxygeldanamycin
• 刊名：Critical Reviews in Oncology and Hematology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：97
• 期：Complete
• 页码：152-156
• 全文大小：612 K

文摘

Ovarian cancer (OC) is a major problem in gynecological oncology. Options for diagnosis and treatment of advanced stages and thus for patient prognosis have not been improved substantially over the past decades. Heat shock proteins (HSP) are characterized as stress-induced molecular chaperones performing cell survival factor functions. In cancer cells, various crucial and clinically important cell responses are vitally influenced and modulated by HSPs, e.g., cell growth and treatment resistance. Despite the limited knowledge on HSPs in OC progression, their roles as biomarkers, prognostic factors and their drug target properties appears promising for future clinical applications and therapeutic approaches.