Safety and immunogenicity of a booster dose of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) in healthy adults: A randomized phase 1 study
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- 作者：Helen Marshalla ; h ; helen.marshall@adelaide.edu.au" class="auth_mail" title="E-mail the corresponding author ; Michael Nissenb ; h ; Peter Richmondc ; Sepehr Shakibd ; Qin Jiange ; David Cooperf ; Denise Rille ; James Baberg ; Joseph Eidenf ; William C. Gruberf ; Kathrin U. Jansenf ; Annaliesa S. Andersonf ; Edward T. Zitoe ; Douglas Girgentif
- 关键词：Staphylococcus aureus ; Vaccine ; Functional antibodies ; Capsular polysaccharide conjugates ; Clumping factor A
- 刊名：Journal of Infection
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：73
- 期：5
- 页码：437-454
- 全文大小：4187 K
文摘
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A booster dose of a 3-antigen Staphylococcus aureus vaccine (SA3Ag) was assessed.
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SA3Ag is a novel multiantigen vaccine that targets S. aureus virulence factors.
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Immune response to the 1st vaccination persisted for 12 months in adults ≤85 years.
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Little or no additional immune response induced by booster dose given at Month 6.
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Injection site reactions post-booster more frequent and severe but self-limiting.