An ancient dental gene set governs development and continuous regeneration of teeth in sharks
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- 作者：Liam J. Rascha ; Kyle J. Martina ; Rory L. Coopera ; Brian D. Metscherb ; Charlie J. Underwoodc ; Gareth J. Frasera ; g.fraser@sheffield.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Shark dentition ; Tooth development ; Dental regeneration ; Dental lamina ; Evo-devo ; Vertebrate evolution
- 刊名：Developmental Biology
- 出版年：2016
- 出版时间：15 July 2016
- 年：2016
- 卷：415
- 期：2
- 页码：347-370
- 全文大小：11763 K
文摘
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Tooth development is highly conserved from sharks to mammals, over 450 million years.
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Sharks regenerate their teeth in a continuous conveyor belt-like manner.
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A core set of dental genes is utilised by all toothed vertebrates.
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The dental lamina is a developmental prerequisite for continuous tooth regeneration.
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All vertebrates share common signalling centres that direct tooth shape morphogenesis.