CPT-11 is an effective anticancer drug, but induced toxicity limits its application in the clinic.
CPT-11 decreased IL-10-producing CD4 T cell frequency in intestinal lamina propria lymphocytes.
CPT-11 altered the composition of bile acid metabolites, notably DCA and TDCA in liver, bile and intestine.
DCA and TDCA potentiated CPT-11-induced suppression of IL-10 secretion by active CD4+ naive T cells.