The Prevalence and Specificity of Depression Diagnosis in a Clinic-Based Population of Adults With Type 2 Diabetes Mellitus

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• 作者：Sherita Hill Golden ; M.D. ; M.H.S.^a ; ^b ; ^{sahill@jhmi.edu} ; Nina Shah ; M.S.^b ; Mohammad Naqibuddin ; M.B.B.S. ; M.P.H.^a ; Jennifer L. Payne ; M.D.^c ; Felicia Hill-Briggs ; Ph.D.^a ; Gary S. Wand ; M.D.^a ; Nae-Yuh Wang ; Ph.D.^a ; ^b ; ^d ; Susan Langan ; M.S. ; M.P.H.^a ; Constantine Lyketsos ; M.D. ; M.H.S.^c
• 关键词：type 2 diabetes mellitus ; major depressive disorder ; minor depression ; anxiety disorders
• 刊名：Psychosomatics
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：58
• 期：1
• 页码：28-37
• 全文大小：263 K
• 卷排序：58

文摘

To estimate the crude prevalence of minor depressive disorder (MinD) in a clinic-based population of adults with type 2 diabetes.MethodsWe screened a clinical sample of 702 adults with type 2 diabetes for depressive symptoms using the Patient Health Questionnaire-2 and performed a structured diagnostic psychiatric interview on 52 screen-positive and a convenience sample of 51 screen-negative individuals. Depressive disorder diagnoses were made using Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) Text Revised criteria and categorized as MinD, major depressive disorder (MDD), or no depressive disorder. We estimated prevalence of MinD and MDD and derived 95% CIs.ResultsThe crude prevalence of current, past, and current or past MinD was 4.3% (95% CI: 0.9–9.2%), 9.6% (95% CI: 3.9–15.9%), and 13.9% (95% CI: 7.7–21.2%), respectively. The crude prevalence of current, past, and current or past MDD was slightly higher—5.0% (95% CI: 1.9–9.4%), 12.0% (95% CI: 6.1–19.5%), and 17.0% (95% CI: 10.1–24.8%), respectively. There was a high prevalence of coexisting anxiety disorders in individuals with MinD (42.2%) and MDD (8.1%). Hemoglobin A1c levels were not significantly different in individuals with MinD or MDD compared to those without a depressive disorder.ConclusionsMinD is comparably prevalent to MDD in patients with type 2 diabetes; both disorders are associated with concomitant anxiety disorders. MinD is not included in the DSM-5; however, our data support continuing to examine patients with chronic medical conditions for MinD.