Photocrosslinkable bioadhesive based on dextran and PEG derivatives
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- 作者：Chunxia Li ; Tao Wang ; Lihui Hu ; Yaohua Wei ; Jianning Liu ; Xueyan Mu ; Jun Nie ; Dongzhi Yang
- 关键词：Dextran ; Poly (ethylene glycol) ; Dopamine hydrochloride ; Tissue adhesive ; Photocrosslinking
- 刊名：Materials Science and Engineering: C
- 出版年：1 February, 2014
- 年：2014
- 卷：35
- 期：Complete
- 页码：300-306
- 全文大小：1229 K
文摘
In this study, a hybrid photopolymeric bioadhesive system consisting of urethane methacrylated dextran (Dex-U) and 3, 4-Dihydroxyphenyl-l-alanine (DOPA) modified three-arm poly (ethylene glycol) s (PEG-DOPAs) was designed. The process of photopolymerization was detected by Photo-Differential Scanning Calorimetry (Photo-DSC). The adhesion strength was evaluated by the lap shear tests. The surface tension of the solutions, burst pressures and the cytotoxicity assays were also investigated. The addition of PEG-DOPAs significantly improved the properties of Dex-U especially in the field of adhesion strength and burst pressure. And materials variation could be tailored to match the demands for tissue repair. Compared to the Dex-U systems, the maximum adhesion strength of the copolymeric system increased from 2.7 卤 0.1 MPa to 4.0 卤 0.6 MPa. Owing to its strong adhesion strength, rapid curing rate and good biocompatibility, such photocrosslinkable hydrogelsa could be applied to the areas of bioadhesive.