Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-κB signaling pathway
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- 作者：Yinhang Yua ; b ; 1 ; Jinjiao Hea ; 1 ; Siming Lie ; Liying Songa ; Xiaochen Guoa ; Wenbing Yaod ; Dehua Zouf ; Xinyu Gaoa ; Yunye Liua ; Fuliang Baia ; Guiping Rena ; c ; Deshan Lia ; c ; deshanli@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：RA ; rheumatoid arthritis ; FGF21 ; fibroblast growth factor 21 ; CIA ; collagen-induced arthritis ; IL-1β ; interleukin-1β ; TNF-α ; tumor necrosis factor ; IL-6 ; interleukin-6 ; IL-17 ; interleukin-17 ; IL-10 ; interleukin-10 ; IFN-γ ; interferon-γ ; ROS ; reactive oxygen species ; MDA ; malondialdehyde ; SOD ; superoxide dismutase ; CAT ; catalase ; GSH-PX ; glutathione peroxidase ; GSH ; glutathione ; LPS ; lipopolysaccharides ; HO-1 ; heme oxygenase-1 ; Nrf2 ; nuclear factor-erythroid 2-related factor 2
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：144-152
- 全文大小：1450 K
文摘
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β-Klotho is expressed in macrophages of the spleen and RAW264.7.
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FGF21 regulated cytokines expression in LPS-stimulated RAW264.7 macrophages.
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FGF21 suppressed oxidative stress in LPS-stimulated RAW 264.7 macrophages.
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FGF21 inhibited NF-κB activation in LPS-stimulated RAW 264.7 macrophages.
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FGF21 induced HO-1 expression and increased Nrf2 levels in RAW264.7 macrophages.