Therapeutic efficacy of three bispecific antibodies on collagen-induced arthritis mouse model
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- 作者：Qingcui Lia ; Guiping Rena ; b ; Liming Xuc ; Qiuying Wanga ; Jianying Qia ; Wenfei Wanga ; Bing Zhoua ; Xiaohui Hana ; Cuiyu Suna ; Qiang Wua ; Yinhang Yua ; Zhongyi Pengd ; Shimin Zhenge ; Deshan Lia ; b ; deshanli@163.com" class="auth_mail
- 关键词：Bispecific antibody ; Rheumatoid arthritis (RA) ; IL-1尾 ; IL-17A
- 刊名：International Immunopharmacology
- 出版年：July 2014
- 年：2014
- 卷：21
- 期：1
- 页码：119-127
- 全文大小：1432 K
文摘
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Three bispecific and neutralizing antibodies (BsAB-1, BsAB-2 and BsAB-3) against both hIL-1尾 and hIL-17A were constructed.
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Three antibodies could block and neutralize IL-1尾 and IL-17A.
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BsAB-1 appears more bene铿乧ial in treatment CIA mice than other two antibodies.