The MINDView brain PET detector, feasibility study based on SiPM arrays

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• 作者：Antonio J. Gonzá ; lez^a ; ^{agonzalez@i3m.upv.es" class="auth_mail" title="E-mail the corresponding author} ; Stan Majewski^b ; Filomeno Sá ; nchez^a ; Sebastian Aussenhofer^c ; Albert Aguilar^a ; Pablo Conde^a ; Liczandro Herná ; ndez^a ; Luis F. Vidal^a ; Roberto Pani^d ; Marco Bettiol^d ; Andrea Fabbri^d ; Julien Bert^e ; Dimitris Visvikis^e ; Carl Jackson^f ; John Murphy^f ; Kevin O&rsquo ; Neill^f ; Jose M. Benlloch^a
• 关键词：Brain PET ; Gamma ray detectors ; Positron Emission Tomography ; Radio Frequency MRI coils ; SiPM array
• 刊名：Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
• 出版年：2016
• 出版时间：11 May 2016
• 年：2016
• 卷：818
• 期：Complete
• 页码：82-90
• 全文大小：3749 K

文摘

The Multimodal Imaging of Neurological Disorders (MINDView) project aims to develop a dedicated brain Positron Emission Tomography (PET) scanner with sufficient resolution and sensitivity to visualize neurotransmitter pathways and their disruptions in mental disorders for diagnosis and follow-up treatment. The PET system should be compact and fully compatible with a Magnetic Resonance Imaging (MRI) device in order to allow its operation as a PET brain insert in a hybrid imaging setup with most MRI scanners. The proposed design will enable the currently-installed MRI base to be easily upgraded to PET/MRI systems.

The current design for the PET insert consists of a 3-ring configuration with 20 modules per ring and an axial field of view of ~15 cm and a geometrical aperture of ~33 cm in diameter. When coupled to the new head Radio Frequency (RF) coil, the inner usable diameter of the complete PET-RF coil insert is reduced to 26 cm. Two scintillator configurations have been tested, namely a 3-layer staggered array of LYSO with 1.5 mm pixel size, with 35×35 elements (6 mm thickness each) and a black-painted monolithic LYSO block also covering about 50×50 mm² active area with 20 mm thickness.

Laboratory test results associated with the current MINDView PET module concept are presented in terms of key parameters׳ optimization, such as spatial and energy resolution, sensitivity and Depth of Interaction (DOI) capability. It was possible to resolve all pixel elements from the three scintillator layers with energy resolutions as good as 10%. The monolithic scintillator showed average detector resolutions varying from 3.5 mm in the entrance layer to better than 1.5 mm near the photosensor, with average energy resolutions of about 17%.