Tbx20 drives cardiac progenitor formation and cardiomyocyte proliferation in zebrafish

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• 作者：Fei Lu ; Adam Langenbacher ; Jau-Nian Chen ; ^{chenjn@mcdb.ucla.edu}
• 关键词：Tbx20 ; Heart development ; Cardiogenesis ; Cardiac progenitor ; Cardiomyocyte proliferation ; Zebrafish
• 刊名：Developmental Biology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：421
• 期：2
• 页码：139-148
• 全文大小：1087 K
• 卷排序：421

文摘

Tbx20 is required for cardiac progenitor cell formation. Tbx20 deficiency results in a diminished cardiac progenitor population. Tbx20 promotes cardiomyocyte proliferation. Tbx20 overexpression causes cardiomegaly. The cardiac expansion activity of Tbx20 requires its T-box and transactivation domains.