VEGF signals induce trailblazer cell identity that drives neural crest migration
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- 作者：Rebecca McLennana ; 1 ; Linus J. Schumacherb ; c ; 1 ; Jason A. Morrisona ; Jessica M. Teddya ; Dennis A. Ridenoura ; Andrew C. Boxa ; Craig L. Semerada ; Hua Lia ; William McDowella ; David Kayc ; Philip K. Mainib ; Ruth E. Bakerb ; Paul M. Kulesaa ; d ; pmk@stowers.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neural crest ; Chick ; Cell migration ; Embryonic microenvironment ; Gene expression ; Molecular profile ; Computational modeling ; Trailblazers
- 刊名：Developmental Biology
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：407
- 期：1
- 页码：12-25
- 全文大小：10853 K
文摘
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Neural crest cells do not display distinct gene expression profiles in culture.
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Timed exposure to VEGF in culture reveals rapid changes in neural crest genes.
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Ectopic VEGF presented to trailer neural crest show migratory stream alterations.
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Gene profiling of trailer cells that divert to VEGF upregulate lead genes.
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Reduction of VEGF signaling within trailer cells does not affect their migration.