Dishing out mini-brains: Current progress and future prospects in brain organoid research

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• 作者：Iva Kelava ; Madeline A. Lancaster ; ^{mlancast@mrc-lmb.cam.ac.uk}
• 关键词：Organoid ; Cortex ; Human brain development ; In vitro ; Neurological disorder ; Neural differentiation ; Stem cells
• 刊名：Developmental Biology
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：420
• 期：2
• 页码：199-209
• 全文大小：2880 K
• 卷排序：420

文摘

Brain organoids currently model early human embryonic and fetal brain development to a remarkably high degree. Brain organoids successfully model several neurodevelopmental conditions – microcephaly, idiopathic autism, Zika infection. Modeling later neurodevelopmental events will require improvements to nutrient supply and sustained culture conditions.