Transient production of artemisinin in Nicotiana benthamiana is boosted by a specific lipid transfer protein from A. annua
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- 作者：Bo Wanga ; 1 ; Arman Beyraghdar Kashkoolia ; 1 ; Adrienne Salletsb ; Hieng-Ming Tinga ; 2 ; Norbert C.A. de Ruijterc ; Linda Olofssond ; Peter Brodeliusd ; Mathieu Pottierb ; Marc Boutryb ; Harro Bouwmeestera ; Alexander R. van der Krola ;
- 关键词：Lipid transfer proteins ; ABC transporters ; Pleiotropic Drug Resistance protein ; Artemisinin ; Artemisia annua ; Nicotiana benthamiana
- 刊名：Metabolic Engineering
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：159-169
- 全文大小：1739 K
文摘
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AaLTP3 and AaPDR2 enhance (DH)AA accumulation in apoplast of N. benthamiana and overall flux through artemisinin pathway.
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AaLTP3 is more effective than AaPDR2 in preventing influx of (DH)AA from the apoplast into the cells.
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First documented case of artemisinin and arteannuin B production in N. benthamiana.