Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents
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- 作者：Subrahmanyam ; Duvvuri ; Renuka ; B. ; Rao ; C.V. Laxmana ; Sagar ; P. Sangeeta ; Deevi ; Dhanvanthri S. ; et. al.
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：1998
- 出版时间：June 2, 1998
- 年：1998
- 卷：8
- 期：11
- 页码：1391-1396
- 全文大小：268 K
文摘
Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occuring podophyllotoxin and determined their in vitro anti-cancer activity. Most of the analogues have shown good activity towards human cancer cell lines.