N′-((2-(6-bromo-2-oxo-2H-chromen-3-yl)-1H-indol-3-yl)methylene)benzohydrazide as a probable Bcl-2/Bcl-xL inhibitor with apoptotic and anti-metastatic potential
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- 作者：Pooja R. Kamatha ; Dhanya Sunila ; dhanyadss3@gmail.com" class="auth_mail" title="E-mail the corresponding author ; A. Abdul Ajeesb ; K.S.R. Paic ; Shubankar Biswasc
- 关键词：Hybrid schiff base ; Cytotoxicity ; Cell cycle ; Apoptosis ; Metastasis ; Bcl-2/Bcl-xL
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：14 September 2016
- 年：2016
- 卷：120
- 期：Complete
- 页码：134-147
- 全文大小：1837 K
文摘
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Synthesis of novel indole-coumarin hybrid schiff bases proposed.
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A new probable Bcl-2/Bcl-xL inhibitor,
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Downregulation of Bcl-2/Bcl-xL protein detected in western blot analysis.
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Profound impairment of MCF-7 cell migration due to Bcl-2 down-regulation induced by