文摘
We discovered a previously unknown hyo-androgenic polycystic ovary syndrome (PCOS) phenotype. Its hypo-androgenism appears adrenal in origin, representing insufficiency of the zona reticularis. Since closely associated with anti-thyroid autoimmunity, it, likely, is also autoimmune in etiology. This, therefore, suggests that, like the other two zonae, the zona-reticularis can also be affected by autoimmunity. Adrenal hypo-androgenism, therefore, has to be considered a potential component of autoimmune adrenal insufficiency.