A comparative evaluation of treatments with 17β-estradiol and its brain-selective prodrug in a double-transgenic mouse model of Alzheimer's disease
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- 作者：Anna E. Tschiffelya ; b ; 1 ; Rosemary A. Schuhc ; d ; Katalin Prokai-Tatraie ; f ; Laszlo Prokaie ; f ; 2 ; Laszlo.Prokai@unthsc.edu" class="auth_mail" title="E-mail the corresponding author ; Mary Ann Ottingerb ; 2 ; 3 ; maotting@central.uh.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Estradiol ; Brain-selective prodrug ; Alzheimer's disease ; Transgenic mice ; Amyloid-β ; Radial arm water maze
- 刊名：Hormones and Behavior
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：39-44
- 全文大小：521 K
文摘
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.Treatment of AD-dtg mice with a brain-selective 17β-estradiol (DHED) decreased APP
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DHED treatment reduced brain amyloid-β peptide levels
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DHED-treated AD-dtg mice had improved cognitive performance
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DHED treatment faithfully replicated positive effects observed for 17β-estradiol
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DHED did not stimulate uterine tissue, whereas 17β-estradiol treatment did.