Association between plasma soluble RAGE and renal function is unaffected by medication usage and enzymatic antioxidants in chronic kidney disease with type 2 diabetes
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- 作者：Foo Nian Wonga ; Jin Ai Mary Anne Tana ; Tee Chau Kengb ; Kok Peng Ngb ; Kek Heng Chuaa ; Umah Rani Kuppusamya ; umah@um.edu.my" class="auth_mail" title="E-mail the corresponding author
- 关键词：CKD ; chronic kidney disease ; D-CKD ; diabetic CKD ; ND-CKD ; non-diabetic CKD ; DM ; diabetic patients without CKD ; Non-DM ; patients without diabetes and CKD ; eGFR ; estimated glomerular filtration rate ; GPx ; glutathione peroxidase ; SOD ; superoxide dismutase ; RAGE ; receptor for advanced glycation end-products ; esRAGE ; endogenous secretory RAGE ; AGE ; advanced glycation end-products ; ADAM10 ; a disintegrin and metalloproteinase domain-containing protein 10 ; MMP-9 ; matrix metalloproteinase-9 ; ROS ; reactiv
- 刊名：Clinica Chimica Acta
- 出版年：2016
- 出版时间：30 January 2016
- 年：2016
- 卷：453
- 期：Complete
- 页码：56-61
- 全文大小：274 K
文摘
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Soluble RAGE was correlated with eGFR in both diabetic and non-diabetic CKD patients.
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The correlation remained unaffected by enzymatic antioxidants in diabetic CKD.
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The correlation was confounded by enzymatic antioxidants in non-diabetic CKD.
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Soluble RAGE is a better indicator of eGFR in diabetic CKD patients.
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Soluble RAGE is unlikely to be an ideal biomarker of non-diabetic CKD.