Core-shell hybrid nanomaterials based on CoFe₂O₄ particles coated with PVP or PEG biopolymers for applications in biomedicine

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• 作者：Cristina Ileana Covaliu^a ; ^{cristina_covaliu@yahoo.com} ; Ioana Jitaru^b ; Gigel Paraschiv^a ; Eugeniu Vasile^c ; Sorin-?tefan Biri?^a ; Lucian Diamandescu^d ; Valentin Ionita^e ; Horia Iovu^b
• 关键词：Cobalt ferrite nanoparticles ; Hybrid nanomaterials ; Polyvinylpyrrolidone (PVP) ; Polyethylene glycol (PEG)
• 刊名：Powder Technology
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：237
• 期：Complete
• 页码：415-426
• 全文大小：2414 K

文摘

Monodisperse core-shell hybrid nanoparticles based on cobalt ferrite (CoFe₂O₄) particles coated with polyvinylpyrrolidone (PVP) or polyethylene glycol (PEG) biopolymers were obtained employing a two-step procedure: the CoFe₂O₄ of 21 nm mean particle size were first synthesized by coprecipitation method assisted by PVP soft template and then were coated by PVP or PEG biopolymers. The effect of the thermal treatment upon the phase evolution of the obtained precursor from the coprecipitation step was monitored by X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses. The FTIR spectra also indicated the interaction between the cobalt ferrite particles and the two polymers were used as biocompatible coatings. Transmission electron microscopy (TEM) and Selected Area Electron Diffraction (SAED) analyses revealed the formation of approximately 22 nm CoFe₂O₄-PVP and CoFe₂O₄-PEG hybrid nanoparticles. The magnetic measurements indicated that all synthesized hybrids were appropriate for applying in biomedical field. Testing the bioeffect of the uncoated cobalt ferrite nanoparticles and corresponding hybrids on Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Salmonella enterica serovar typhimurium bacteria and Candida scotti yeast it was clear that no significant toxic activity was obtained. Moreover, all the prepared nanohybrids and their components possess antioxidant activity.