文摘
Gains on 16q24.3 associate with FancA overexpression and impaired overall survival. FancA overexpression confers radioresistance with improved DNA repair in vitro. No hyperactivation of the FA/BRCA-pathway is observed. Interferon signaling is attenuated, senescence, and SASP production are enforced. FancA-associated transcriptomic alterations are reflected in clinical HNSCC samples.