Diarylheptanoids from Alnus nepalensis attenuates LPS-induced inflammation in macrophages and endotoxic shock in mice
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- 作者：Archana Saxenaa ; Deepti Yadavb ; Anil K. Mauryaa ; Anant Kumara ; Shilpa Mohantya ; Madan M. Guptab ; Madhu C. Lingarajuc ; M.I. Yatood ; Uttam S. Thakurc ; Dnyaneshwar U. Bawankulea ; du.bawankule@cimap.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alnus nepalensis ; Diarylheptanoids ; Inflammation ; Macrophages ; Mice
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：129-136
- 全文大小：840 K
文摘
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ANB was most effective extract of Alnus nepalensis against pro-inflammatory cytokine production.
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HPLC analysis of ANB showed the presence of diarylheptanoids.
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Platyphylloside from ANB is the most active anti-inflammatory diarylheptanoids.
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In-vivo study revealed that ANB inhibits production pro-inflammatory cytokines,
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ANB also improves organ injury and survival rate in sepsis model without any toxic effect at higher dose in mice.