Development of a novel catalytic amyloid displaying a metal-dependent ATPase-like activity

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• 作者：Octavio Monasterio ; Esteban Nova ; Rodrigo Diaz-Espinoza ; ^{rodrigo.diaz.e@u.uchile.cl}
• 关键词：Amyloid ; Peptide ; Catalysis ; Hydrolysis ; ATP ; Manganese
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1194-1200
• 全文大小：907 K
• 卷排序：482

文摘

A small peptide aggregates into amyloids in a metal-dependent manner at pH 8.0 The peptide catalyzes the hydrolysis of ATP into ADP and AMP using manganese. Amyloid formation is required for the activity. Metal-interacting acidic residues can be catalytic in the amyloid conformation. Biologically relevant molecules can be target for reactive amyloids.