Spectroscopic investigation on the mechanism of formation of molecular complexes of albendazole and trimethoprim with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone

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• 作者：K. Ganesh ; C. Balraj ; A. Satheshkumar ; K.P. Elango ; ^{drkpelango@rediffmail.com}
• 关键词：Charge transfer ; Trimethoprim ; Albendazole ; DDQ ; Fluorescence ; Solvent effect
• 刊名：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
• 出版年：2012
• 出版时间：15 June, 2012
• 年：2012
• 卷：92
• 期：Complete
• 页码：46-55
• 全文大小：789 K

文摘

UV-vis, ¹H NMR, FT-IR, mass and fluorescence spectral techniques were employed to investigate the mechanism of interaction of albendazole and trimethoprim with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and to characterize the reaction products. The interaction of DDQ with trimethoprim (TMP) and albenadazole (ALB) were found to proceed through the formation of donor-acceptor complex, containing DDQ radical anion and its conversion to the product. Fluorescence quenching studies indicated that the interaction between the donors and the acceptor are spontaneous and the interaction of TMP-DDQ (binding constant = 2.9 ¡Á 10⁵) is found to be stronger than that the ALB-DDQ (binding constant = 3 ¡Á 10³) system. Also, the binding constant increased with an increase in polarity of the medium indicating the involvement of radical anion as intermediate.