Thermal analysis: A further step in characterizing solid forms obtained by screening crystallization of an API

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• 作者：Thibaud Detoisien ; Marine Arnoux ; Pascal Taulelle ; Didier Colson ; Jean Paul Klein ; Sté ; phane Veesler
• 关键词：Crystallization ; Polymorphism ; Thermal analysis
• 刊名：International Journal of Pharmaceutics
• 出版年：2011
• 出版时间：17 January 2011
• 年：2011
• 卷：403
• 期：1-2
• 页码：29-36
• 全文大小：1785 K

文摘

Phase and habit selection is a very important step in the early stages of pharmaceutical development of new APIs. In this paper, we show how observation, diffraction and thermal analysis are complementary methods of solid habit and phase characterization. At the end of phase screening of an API several habits and phases can be discriminated by microscopy, XRPD or Raman spectroscopy. Using thermal methods here allows us to separate the 12 phases discriminated by XRPD into: anhydrous, monohydrate, organic monosolvate and heterosolvate phases.