Non-Gaussian diffusion alterations on diffusion kurtosis imaging in patients with early Alzheimer’s disease
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- 作者：Lixiang Yuana ; Man Suna ; b ; Yuanyuan Chenc ; Miaomiao Longa ; Xin Zhaoc ; Jianzhong Yina ; Xu Yand ; Dongxu Jia ; Hongyan Nia ; nihyan@sina.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; Diffusion kurtosis imaging ; Voxel-based analysis ; Non-Gaussian
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：11 March 2016
- 年：2016
- 卷：616
- 期：Complete
- 页码：11-18
- 全文大小：2139 K
文摘
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MR diffusion imaging has advantage in studying brain microstructural changes of AD.
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The Gaussian model, diffusion tensor imaging (DTI) has its drawback in biological tissues.
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Diffusion kurtosis imaging (DKI) can solve those problems.
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This voxel-based DKI study of the AD whole brain showed that early AD patients already have microstructural changes in both white matter (WM) and gray matter (GM).
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DKI can provide supplementary information in reflecting these changes and may be more sensitive than DTI in diagnosing early AD.