Hypercholesterolemia blunts the oxidative stress elicited by hypertension in venules through angiotensin II type-2 receptors
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- 作者：Alper Yildirim ; Elena Senchenkova ; D. Neil Granger ; dgrang@lsuhsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HTN ; Hypertension ; HCh ; Hypercholesterolemia ; HCD ; High cholesterol diet ; WT ; Wild type ; AngII ; Angiotensin II ; ROS ; Reactive oxygen species ; AT2r ; Angiotensin II type- 2 receptor ; CVD ; Cardiovascular disease ; RAS ; Renin-angiotensin system ; AT1r ; Angiotensin II type-1 receptors ; ApoE&minus ; /&minus ; ; Apolipoprotein E knockout ; DHR ; Dihydrorhodamine ; BBS ; Bicarbonate-buffered saline ; PD123319 ; Angiotensin II type-2 receptor antagonist ; APS ; Antiplatelet serum ; Gr-1 ; Anti-granulocyte receptor
- 刊名：Microvascular Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：54-60
- 全文大小：711 K
文摘
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Hypercholesterolemia protects against hypertension-induced leukocyte recruitment.
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Hypercholesterolemia blunts oxidant stress during AngII-induced hypertension.
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Angiotensin-II type 2 receptors mediate these responses to hypercholesterolemia.