Active immunization with the peptide epitope vaccine Aβ3-10-KLH induces a Th2-polarized anti-Aβ antibody response and decreases amyloid plaques in APP/PS1 transgenic mice
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- 作者：Li Ding dingding8766@163.com" class="auth_mail" title="E-mail the corresponding author ; Yuan Meng ; Hui-Yi Zhang ; Wen-Chao Yin ; Yi Yan ; Yun-Peng Cao ; cypcmu@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; Amyloid-β peptide ; Epitope vaccine ; Carrier protein ; Multiple-antigen peptides
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：634
- 期：Complete
- 页码：1-6
- 全文大小：1582 K
文摘
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Two novel peptide vaccines, Aβ3-10-KLH and 5Aβ3-10, were developed.
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Aβ3-10-KLH induced high levels of Aβ-specific antibodies in APP/PS1 transgenic mice.
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Aβ3-10-KLH elicited Th2-polarized immune responses in APP/PS1 transgenic mice.
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Aβ3-10-KLH inhibited cerebral Aβ deposition in APP/PS1 transgenic mice.
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5Aβ3-10 did not induce effective humoral immune responses in APP/PS1 transgenic mice.