Altered cytokine profile, pain sensitivity, and stress responsivity in mice with co-disruption of the developmental genes Neuregulin-1 × DISC1

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• 作者：Lieve Desbonnet^a ; ^b ; Rachel Cox^a ; Orna Tighe^a ; Donna Lai^c ; Richard P. Harvey^c ; John L. Waddington^a ; Colm M.P. O&rsquo ; Tuathaigh^a ; ^d ; ^{c.otuathaigh@ucc.ie}
• 关键词：Neuregulin-1 ; Disrupted-in-schizophrenia-1 ; Anxiety ; Stress responsivity ; Cytokines
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：320
• 期：Complete
• 页码：113-118
• 全文大小：848 K
• 卷排序：320

文摘

Anxiety and stress responsivity were examined in mutant mice with simultaneous disruption of schizophrenia-associated genes NRG1 and DISC1. Mice with partial knockout of NRG1 displayed reduced anxiety-related behaviour and stress-reactivity. Disruption of DISC1 but not of NRG1, in the absence of epistasis, was associated with increased basal serum pro-inflammatory cytokine levels. Simultaneous NRG1-DISC1 mutation diminishes the DISC1-specific increases in the pro-inflammatory cytokines IL6 and TNF-α.