Animal models of respiratory syncytial virus infection

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• 作者：Geraldine Taylor ^{geraldine.taylor@pirbright.ac.uk}
• 关键词：Respiratory syncytial virus ; Animal models
• 刊名：Vaccine
• 出版年：2017
• 出版时间：11 January 2017
• 年：2017
• 卷：35
• 期：3
• 页码：469-480
• 全文大小：1610 K
• 卷排序：35

文摘

Respiratory syncytial virus (RSV) is a major cause respiratory disease, worldwide. Paediatric and elderly populations are most vulnerable to severe disease. Vaccine development has been hampered by the experience of vaccine-enhanced disease. Animal models do not necessarily predict vaccine efficacy and safety. The strengths and limitations of animal models of RSV infection are summarised.