An SVIR model with vaccination and treatment as interventions and corresponding optimal control problem for these interventions is considered.

Total cost includes costs due to opportunity loss, vaccination efforts (4^th degree nonlinear) and treatment efforts (quadratic).

Existence of controls is guaranteed analytically and corresponding optimal control functions are obtained analytically.

Three strategies are defined: A) with vaccination only; B) with vaccination and treatment, for control of disease and C) with treatment only.

Numerically we find: (i) strategy A)- less effective & expensive if vaccination is not highly effective; (ii) Strategy B)- best & least expensive.

Strategy B) not only minimizes cost burden due to opportunity loss and applied control policies but also keeps a tab on infective population.