Non-syndromic cleft lip with or without cleft palate in Asian populations: Association analysis on three gene polymorphisms of the folate pathway
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- 作者：Marcella Martinellia ; marcella.martinelli@unibo.it" class="auth_mail" title="E-mail the corresponding author ; Ambra Girardia ; Francesca Curaa ; Nayereh Nourib ; Valentina Pintoc ; Francesco Carincid ; Paolo Giovanni Morsellia ; Mansoor Salehie ; Luca Scapolia
- 关键词：OFC ; orofacial cleft ; CL/P ; cleft lip with or without cleft palate ; CPO ; cleft palate only ; NSCL/P ; non-syndromic cleft lip with or without cleft palate ; MTHFR ; methylenetetrahydrofolate reductase ; TCN2 ; transcobalamin 2 ; CBS ; cystathionine beta-synthase ; SNP ; single nucleotide polymorphism ; TDT ; transmission disequilibrium test
- 刊名：Archives of Oral Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：61
- 期：Complete
- 页码：79-82
- 全文大小：291 K
文摘
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The study investigated three candidate genes for cleft lip with or without palate.
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The T allele of MTHFR C677T polymorphism reduces the risk of cleft in Asians.
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This result conflicts with previous studies.