Emergence of extended-spectrum 尾-lactamase-producing Escherichia coli in catheter-associated urinary tract infection in neurogenic bladder patients

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• 作者：Kei Takaba ; BS^a ; Katsumi Shigemura ; MD ; PhD^b ; ^c ; ^{yutoshunta@hotmail.co.jp" class="auth_mail} ; Kayo Osawa ; PhD^c ; Masashi Nomi ; MD ; PhD^d ; Masato Fujisawa ; MD ; PhD^b ; Soichi Arakawa ; MD ; PhD^b ; ^c
• 关键词：Catheter-associated urinary tract infection (CAUTI) ; Extended-spectrum 尾-lactamase (ESBL)-producing Escherichia coli ; Repetitive-sequence-based polymerase chain reaction (rep-PCR)
• 刊名：American Journal of Infection Control
• 出版年：March, 2014
• 年：2014
• 卷：42
• 期：3
• 页码：e29-e31
• 全文大小：274 K

文摘

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Background

Catheter-associated urinary tract infection (CAUTI) is a common clinic problem. The purpose of this study was to investigate recent trends in CAUTI in neurogenic bladder patients focusing on extended-spectrum 尾-lactamase (ESBL)-producing Escherichia coli.

Methods

Isolates from the urine of neurogenic bladder patients with UTI were investigated. Nine strains of ESBL-producing E coli were assayed by molecular strain typing using the Diversilab system for repetitive-sequence-based polymerase chain reaction (rep-PCR).

Results

E coli accounted for most of the bacteria (74.1% to 81.0%) that produced ESBLs. Rep-PCR data showed that 7 out of 9 ESBL-producing E coli belonged to the same typing group with high similarity (more than 97% similarity) and that this distribution corresponded with antibiotic resistance patterns.

Conclusion

ESBL producing E coli strains isolated from CAUTI patients could be discriminated by rep-PCR typing using the Diversilab system in consistent with antibiotic resistance patterns.