DMSO modulates CNS function in a preclinical Alzheimer's disease model

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• 作者：Lorè ; ne Penazzi^a ; Julia Lorengel^a ; Frederik Sü ; ndermann^a ; Nataliya Golovyashkina^a ; Stefan Marre^a ; Chantal M.B. Mathis^c ; Lars Lewejohann^b ; Roland Brandt^a ; Lidia Bakota^a ; ^{bakota@biologie.uni-osnabrueck.de}
• 关键词：DMSO ; Aβ ; Spines ; Spatial memory ; Anxiety ; Odor habituation
• 刊名：Neuropharmacology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：113
• 期：part_PA
• 页码：434-444
• 全文大小：2317 K
• 卷排序：113

文摘

Low amounts of DMSO modulate spine density in APPSDL mice ex vivo and in vivo. DMSO tends to enhance hippocampal-dependent spatial memory accuracy in APPSDL mice. DMSO modulates hippocampal-independent olfactory habituation in APPSDL mice. DMSO displays anxiolytic effect in APPSDL mice.