Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis
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- 作者：Olaug Kristin Rø ; dningen ; Anne-Lise Bø ; rresen-Dale ; Jan Alsner ; Trevor Hastie ; Jens Overgaard
- 关键词：Ionizing radiation ; Radiation-induced fibrosis ; Gene expression ; cDNA microarray ; Fibroblasts ; Prediction
- 刊名：Radiotherapy and Oncology
- 出版年：2008
- 出版时间：March 2008
- 年：2008
- 卷：86
- 期：3
- 页码：314-320
- 全文大小：111 K
文摘
Breast cancer patients show a large variation in normal tissue reactions after ionizing radiation (IR) therapy. One of the most common long-term adverse effects of ionizing radiotherapy is radiation-induced fibrosis (RIF), and several attempts have been made over the last years to develop predictive assays for RIF. Our aim was to identify basal and radiation-induced transcriptional profiles in fibroblasts from breast cancer patients that might be related to the individual risk of RIF in these patients.