FABP4 and miR-148a/152 were upregulated and DNMT1 was downregulated in placentae of pregnant rats and HTR-8 cells.
DNMT1 overexpression increased FABP4 DNA methylation and decreased its expression in HTR-8 cells.
DNMT1 is a direct target of miR-148a/152.
miR-148a/152 caused FABP4 hypomethylation by targeting DNMT1 in preeclampsia.
FABP4 is a potential therapeutic target for preeclampsia.