Distinct and overlapping DNMT1 interactions with multiple transcription factors in erythroid cells: Evidence for co-repressor functions
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- 作者：Dimitris N. Papageorgioua ; Elena Karkouliaa ; 1 ; Alexandra Amaral-Psarrisa ; Pavel Burdab ; Katarzyna Kolodziejc ; Jeroen Demmersd ; Jö ; rg Bungerte ; Tomas Stopkaf ; John Strouboulisa ; john_strouboulis@imbb.forth.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：DNMT1 ; Transcription factors ; Erythropoiesis ; Epigenetics
- 刊名：Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：1859
- 期：12
- 页码：1515-1526
- 全文大小：1345 K
文摘
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DNMT1 interacts with several hematopoietic transcription factors in erythroid cells.
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DNMT1 interacts with transcription factors through its 17aa PBD domain.
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DNMT1 serves as a co-repressor to these transcription factors.
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DNMT1 binds in vivo to repressed gene loci serving important hematopoietic functions.