Association between DNA methyltransferase gene polymorphism and Parkinson’s disease

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• 作者：Julio Carlos Pezzi^a ; ^{julio.pe@hotmail.com} ; Cintia Monique Boschmann Ens de Bem^a ; Tatiane Jacobsen da Rocha^a ; Artur F. Schumacher-Schuh^b ; ^c ; Marcia Lorena Fagundes Chaves^c ; Carlos Roberto Rieder^b ; ^c ; Mara H. Hutz^b ; Marilu Fiegenbaum^a ; Ana Luiza Camozzato^a ; ^{anacamoz@gmail.com}
• 关键词：Pakinson&rsquo ; s disease ; Single nucleotide polymorphism ; Methyltransferases ; Epigenomics
• 刊名：Neuroscience Letters
• 出版年：2017
• 出版时间：3 February 2017
• 年：2017
• 卷：639
• 期：Complete
• 页码：146-150
• 全文大小：515 K
• 卷排序：639

文摘

This study first investigated the association among DNMT1 and DNMT3B polymorphisms with Parkinson Disease (PD) and showed an original result. The DNMT3B polymorphism rs2424913 was associated with Parkinson’s Disease (PD). The presence of the T allele increased the odds ratio to PD. No significant difference was observed for others SNPs investigated in DNMT3B and DNMT1. This association suggests a role for a DNA methylation enzyme in PD, highlighting the hypothesis of epigenetic mechanisms to PD pathogenesis.