Molecular diagnosis of bacterial vaginosis: Does adjustment for total bacterial load or human cellular content improve diagnostic performance?

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• 作者：E.L. Plummer^a ; ^b ; ^{erica.plummer@mcri.edu.au} ; S.M. Garland^a ; ^b ; ^c ; C.S. Bradshaw^d ; ^e ; M.G. Law^f ; L.A. Vodstrcil^a ; ^d ; ^e ; J.S. Hocking^e ; C.K. Fairley^d ; S.N. Tabrizi^a ; ^b ; ^g
• 关键词：Bacterial vaginosis ; Molecular diagnosis ; qPCR
• 刊名：Journal of Microbiological Methods
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：133
• 期：Complete
• 页码：66-68
• 全文大小：205 K
• 卷排序：133

文摘

Utility of qPCR assays for molecular diagnosis of bacterial vaginosis is investigated. Adjusting assays for human cell load does not improve diagnostic performance. Adjusting for total bacterial load does not consistently improve diagnostic accuracy. Elevated loads of G. vaginalis and A. vaginae are predictive of bacterial vaginosis.