Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22
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- 作者：Masazumi Wasedaa ; Sumimasa Arimuraa ; Eri Shimurab ; 1 ; Susumu Nakaeb ; c ; Yuji Yamanashia ; yyamanas@ims.u-tokyo.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：DSS ; Colitis ; Dok ; Th17 cytokines
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：9 September 2016
- 年：2016
- 卷：478
- 期：1
- 页码：135-142
- 全文大小：2400 K
文摘
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Dok-1 and Dok-2 play a cooperative role in protection against DSS-induced colitis.
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Dok-1/-2 double KO (DKO) mice show extensive ulceration of the colon after DSS treatment.
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Proliferation of colonic epithelium is inhibited in DSS-treated Dok-1/-2 DKO mice.
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Expression of IL-17A and IL-22 is reduced in the colon of DSS-treated Dok-1/-2 DKO mice.