NSD3-Short Is an Adaptor Protein that Couples BRD4 to the CHD8 Chromatin Remodeler
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- 作者：Chen Shen1 ; 2 ; Jonathan J. Ipsaro1 ; 3 ; Junwei Shi1 ; 2 ; Joseph P. Milazzo1 ; Eric Wang1 ; Jae-Seok Roe1 ; Yutaka Suzuki4 ; Darryl J. Pappin1 ; Leemor Joshua-Tor1 ; 3 ; Christopher R. Vakoc1 ; vakoc@cshl.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：17 December 2015
- 年：2015
- 卷：60
- 期：6
- 页码：847-859
- 全文大小：5022 K
文摘
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A short isoform of NSD3 lacking catalytic function is essential in leukemia
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NSD3-short is an adaptor protein that links BRD4 to the CHD8 chromatin remodeler
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NSD3-short also uses a PWWP module and an acidic activation domain in leukemia
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BRD4-NSD3-CHD8 complexes are evicted from chromatin by BET inhibitors