DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines
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- 作者：Dulamsuren Oktyabria ; Akihiko Ishimuraa ; b ; Shoichiro Tangea ; Minoru Terashimaa ; Takeshi Suzukia ; b ; suzuki-t@staff.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cancer progression ; Cell migration ; Histone methyltransferase ; Sphere formation ; Transcriptional regulation
- 刊名：Biochimie
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：20-31
- 全文大小：2484 K
文摘
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DOT1L histone methyltransferase is up-regulated in malignant breast cancers.
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DOT1L is involved in sphere formation and cell migration of breast cancer cell lines.
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DOT1L regulates the expression of BCAT1 through histone H3K79 methylation.
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BCAT1 is responsible for DOT1L-mediated cell migration and sphere formation.