Leukemogenic MLL-ENL Fusions Induce Alternative Chromatin States to Drive a Functionally Dichotomous Group of Target Genes
详细信息 查看全文
- 作者：Maria-Paz Garcia-Cuellar1 ; Christian Bü ; ttner2 ; Christoph Bartenhagen3 ; Martin Dugas3 ; Robert K. Slany1 ; robert.slany@fau.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：leukemia ; chromatin ; MLL-ENL ; P-TEFb ; DOT1L ; inhibitors
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：12 April 2016
- 年：2016
- 卷：15
- 期：2
- 页码：310-322
- 全文大小：5420 K
文摘
- •
MLL-ENL has two distinct groups of downstream targets
- •
Target gene transcription depends on either DOT1L or P-TEFb activity
- •
Dichotomous transcription mode is consistent with separate biological function
- •
Target gene families respond differently to pharmacological inhibitors