Bardoxolone methyl prevents the development and progression of cardiac and renal pathophysiologies in mice fed a high-fat diet
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- 作者：Danielle Camera ; Yinghua Yua ; Alexander Szaboa ; b ; Hongqin Wanga ; Chi H.L. Dinha ; Xu-Feng Huanga ; xhuang@uow.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：High-fat diets ; Obesity ; Bardoxolone methyl ; Heart ; Kidney
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：243
- 期：Complete
- 页码：10-18
- 全文大小：2011 K
文摘
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Bardoxolone methyl (BM) prevents high-fat (HF) diet-induced cardiac hypertrophy.
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BM prevents HF diet-induced renal corpuscle hypertrophy.
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BM prevents HF diet-induced fat accumulation and inflammation in the heart.
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BM prevents HF diet-induced fat accumulation and inflammation in the kidneys.
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BM prevents HF diet-induced elevations in renal endothelin signalling.