Synthesis of a monophasic nanohybrid for a controlled release formulation of two active agents simultaneously

详细信息    查看全文

• 作者：Mohd Zobir Hussein^a ; ^b ; ^{mzobir@science.upm.edu.my} ; Nor Shazlirah Shazlyn Abdul Rahman^a ; Siti Halimah Sarijo^c ; Zulkarnain Zainal^a ; ^b
• 关键词：4-(2 ; 4-dichlorophenoxy)butyrate ; 2-(3-chlorophenoxy)propionate ; Herbicides ; Layered double hydroxide ; Anion-exchange ; Controlled release
• 刊名：Applied Clay Science
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：58
• 期：Complete
• 页码：60-66
• 全文大小：944 K

文摘

A new monophasic nanohybrid containing two phenoxyherbicides anions, 4-(2,4-dichlorophenoxy)butyrate (DPBA) and 2-(3-chlorophenoxy)propionate (CPPA), was successfully synthesized. The two anions were simultaneously intercalated into the inorganic interlayers of zinc-aluminum-layered double hydroxide (ZAL) for the formation of a nanohybrid, ZAL-CPPA-DPBA (NCDX) by an anion-exchange method. Powder X-ray diffraction, direct-injection mass spectrometry and Fourier transform infrared spectroscopy studies confirmed the dual intercalation of both anions into the host interlayer regions. The well-ordered, layered nanohybrid was synthesized using 0.1 M solution of both anions. The basal spacing expanded from 8.9 ? in ZAL to 27.43 ? in the nanohybrid. The release of both anions from the nanohybrid into an aqueous solution of 0.001 M sodium carbonate was found to be governed by pseudo second-order kinetics. This release demonstrates the potential application of layered materials as reservoirs and delivery system, especially when multiple active agents are used simultaneously in the formation of an organic-inorganic host-guest nanohybrid with controlled-release properties.