- 作者：Arsè ; ne Zongo ; DPharm ; MSca ; b ; c ; Line Gué ; nette ; BPharm ; PhDa ; b ; c ; Jocelyne Moisan ; PhDa ; b ; c ; Jean-Pierre Gré ; goire ; BPharm ; PhD ; FCAHSa ; b ; c ; Jean-Pierre.Gregoire@pha.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：glycemic control (A1C) ; medication adherence ; noninsulin antidiabetic treatment ; predictive validity ; self-report ; type 2 diabetes
- 刊名：Canadian Journal of Diabetes
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：40
- 期：1
- 页码：58-65
- 全文大小：273 K
Methods
A convenience sample of 153 patients with type 2 diabetes completed a self-report with 4 items (SR-4) and a French version of the Morisky Medication Adherence Scale with 8 items (MMAS-8), reported the proportion of pills missed, and answered a single-item scale regarding their antidiabetes drug treatments. They also provided measures of glycated hemoglobin (A1C) taken between 3 and 6 months after the adherence measurements. We examined the relationship between self-reported adherence and glycemic control using the area under the receiver operating characteristics curve (AUC) and linear regression analyses.
Results
AUCs were 0.51, 0.52, 0.53 and 0.52 for the SR-4, MMAS-8, self-reported proportion of pills missed and single-item scale, respectively. AUCs stratified according to median duration of diabetes ranged from 0.55 to 0.63. Based on linear regression analyses adjusted for diabetes duration, the association measured in the total sample between adherence measures and A1C levels was not statistically significant. When regression analyses were performed among participants with A1C levels ≥7% only, SR-4, MMAS-8 and the single-item scale scores were significantly associated with A1C levels, and beta coefficients were associated with a 1-unit increase in adherence scores of −0.46, −0.20 and 0.38, respectively.
Conclusion
The results support the predictive validity of all measures except the self-reported proportion of missed pills.