Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit
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- 作者：Hind Medyouf1 ; 11 ; 13 ; hind.medyouf@uniklinikum-dresden.de" class="auth_mail ; Maximilian Mossner2 ; Johann-Christoph Jann2 ; Florian Nolte2 ; Simon Raffel3 ; Carl Herrmann4 ; 5 ; Amelie Lier3 ; Christian Eisen3 ; Verena Nowak2 ; Bettina Zens1 ; 3 ; Katja Mü ; dder1 ; 3 ; Corinna Klein1 ; 3 ; Julia Oblä ; nder2 ; Stephanie Fey2 ; Jovita Vogler2 ; Alice Fabarius2 ; Eva Riedl6 ; Henning Roehl7 ; Alexander Kohlmann8 ; Marita Staller8 ; Claudia Haferlach8 ; Nadine Mü ; ller2 ; Thilo John9 ; Uwe Platzbecker10 ; Georgia Metzgeroth2 ; Wolf-Karsten Hofmann2 ; Andreas Trumpp1 ; 3 ; 11 ; 12 ; a.trumpp@dkfz-heidelberg.de" class="auth_mail ; andreas.trumpp@hi-stem.de" class="auth_mail ; Daniel Nowak2 ; 12
- 刊名：Cell Stem Cell
- 出版年：5 June 2014
- 年：2014
- 卷：14
- 期：6
- 页码：824-837
- 全文大小：4466 K
文摘
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Disease-initiating cells in lower-risk MDS are restricted to Lin−CD34+CD38− subset
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Myelodysplastic cells in patients reprogram mesenchymal stromal cells
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Reprogrammed MSCs are essential for propagation of myelodysplastic syndromes
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MDS and niche cells interact via bidirectional signaling crosstalk